Roguelite campaigns and fishing my white whale out of a hole

Recently I have been enjoying rogue-likes and rogue-lites like Nubby's Number Factory, Dungeon Clawer and Enter the Gungeon. These games are randomly generated so that each run is different from the next. They also have permadeath. Once your little creature dies, you have to start from the beginning in a new maze. There are many disagreements on what a rogue-like is, almost as many disagreements as the question "What is the OSR?". My white whale campaign is a rogue-lite campaign. I thought it would be easy as Rogue, the first rogue-like, the start of the genre, was inspired by the high fantasy setting of dungeons and dragons. Unfortunately I have done nothing but get closer and closer not quite getting close enough. Traditional games like 5e or Pathfinder want the GM to make balanced combats which doesn't find the randomized nature of rogue-likes so they won't do. OSR games are my best bet as they have dungeon-centric gameplay and due to the simpler character co...